{ "_id": "6a13fa92acfb0bcc41d353f0", "Package": "hscovar", "Type": "Package", "Title": "Calculation of Covariance Between Markers for Half-Sib Families", "Version": "0.4.2", "Date": "2021-04-13", "Authors@R": "c(person(\"Dörte\",\"Wittenburg\", role = c(\"aut\", \"cre\"), \nemail = \"wittenburg@fbn-dummerstorf.de\"),\nperson(\"Michael\", \"Doschoris\", role = \"aut\"),\nperson(\"Jan\", \"Klosa\", role = \"ctb\"))", "Description": "The theoretical covariance between pairs of markers is\ncalculated from either paternal haplotypes and maternal linkage\ndisequilibrium (LD) or vise versa. A genetic map is required.\nGrouping of markers is based on the correlation matrix and a\nrepresentative marker is suggested for each group. Employing\nthe correlation matrix, optimal sample size can be derived for\nassociation studies based on a SNP-BLUP approach. The\nimplementation relies on paternal half-sib families and\nbiallelic markers. If maternal half-sib families are used, the\nroles of sire/dam are swapped. Multiple families can be\nconsidered. Wittenburg, Bonk, Doschoris, Reyer (2020) \"Design\nof Experiments for Fine-Mapping Quantitative Trait Loci in\nLivestock Populations\" .\nCarlson, Eberle, Rieder, Yi, Kruglyak, Nickerson (2004)\n\"Selecting a maximally informative set of single-nucleotide\npolymorphisms for association analyses using linkage\ndisequilibrium\" .", "License": "GPL (>= 2)", "Encoding": "UTF-8", "LazyData": "true", "RoxygenNote": "7.1.1", "NeedsCompilation": "no", "Packaged": { "Date": "2026-05-25 07:27:29 UTC", "User": "root" }, "Author": "Dörte Wittenburg [aut, cre], Michael Doschoris [aut], Jan Klosa\n[ctb]", "Maintainer": "Dörte Wittenburg ", "Config/pak/sysreqs": "libxml2-dev", "Repository": "https://wittenburg.r-universe.dev", "Date/Publication": "2021-04-13 06:20:06 UTC", "RemoteUrl": "https://github.com/cran/hscovar", "RemoteRef": "HEAD", "RemoteSha": "4d08292cdd561dc3d176b8c22400e9abd5654359", "MD5sum": "36d9c3e1c103d7a735581f27bbe29baf", "_user": "wittenburg", "_type": "src", "_file": 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