Package: hscovar
Type: Package
Title: Calculation of Covariance Between Markers for Half-Sib Families
Version: 0.4.2
Date: 2021-04-13
Authors@R: c(person("Dörte","Wittenburg", role = c("aut", "cre"), 
    email = "wittenburg@fbn-dummerstorf.de"),
    person("Michael", "Doschoris", role = "aut"),
    person("Jan", "Klosa", role = "ctb"))
Description: The theoretical covariance between pairs of markers is
        calculated from either paternal haplotypes and maternal linkage
        disequilibrium (LD) or vise versa. A genetic map is required.
        Grouping of markers is based on the correlation matrix and a
        representative marker is suggested for each group. Employing
        the correlation matrix, optimal sample size can be derived for
        association studies based on a SNP-BLUP approach. The
        implementation relies on paternal half-sib families and
        biallelic markers. If maternal half-sib families are used, the
        roles of sire/dam are swapped. Multiple families can be
        considered. Wittenburg, Bonk, Doschoris, Reyer (2020) "Design
        of Experiments for Fine-Mapping Quantitative Trait Loci in
        Livestock Populations" <doi:10.1186/s12863-020-00871-1>.
        Carlson, Eberle, Rieder, Yi, Kruglyak, Nickerson (2004)
        "Selecting a maximally informative set of single-nucleotide
        polymorphisms for association analyses using linkage
        disequilibrium" <doi:10.1086/381000>.
Depends: R (>= 3.5.0)
Imports: parallel, Matrix, foreach, rlist, pwr
License: GPL (>= 2)
Encoding: UTF-8
LazyData: true
RoxygenNote: 7.1.1
NeedsCompilation: no
Packaged: 2026-07-05 04:58:05 UTC; root
Author: Dörte Wittenburg [aut, cre], Michael Doschoris [aut], Jan Klosa
        [ctb]
Maintainer: Dörte Wittenburg <wittenburg@fbn-dummerstorf.de>
Config/pak/sysreqs: libxml2-dev
Repository: https://wittenburg.r-universe.dev
Date/Publication: 2021-04-13 06:20:06 UTC
RemoteUrl: https://github.com/cran/hscovar
RemoteRef: HEAD
RemoteSha: 4d08292cdd561dc3d176b8c22400e9abd5654359